You can set a virtual disk to independent mode to exclude the disk from any snapshots taken of its virtual machine.
Power off the virtual machine and delete any existing snapshots before you change the disk mode. Deleting a snapshot involves committing the existing data on the snapshot disk to the parent disk.
Virtual machine.State.Remove Snapshot
Virtual machine.Configuration.Modify device settings
1. Select a virtual machine.
2. In the VM Hardware panel, click Edit Settings.
3. Click Virtual Hardware.
4. Click the triangle to display the settings for the disk to exclude from snapshots.
5. Select one of the independent disk mode options.
a. Independent –Persistent
b. Independent –Non Persistent
6. Click OK